A complete overview of Palbociclib for breast cancer treatment

Palbociclib is used in targeted biological therapy for treating locally advanced as well as secondary breast cancer. It is either prescribed alone or in combination with hormone therapy. The drug interferes with the cancer cell multiplication process and stops the further growth of tumors. Usually, Palbociclib is responsible for blocking the proteins that have a chance of becoming overactive and stimulating breast cancer cells to increase in number.

Dosage and Usage of Palbociclib 

Palbociclib dosage varies from patient to patient. It mostly depends on the stage of cancer and the body’s capability to tolerate the side effects. Make sure to follow the prescribed dose regularly to avoid any complications. This drug is available in hard capsule form that needs to be swallowed with water or other liquids. You can take it with or without food, as guided by your physician. 

The typical oral dosage is Palbociclib 125 mg for adults- once a day for 3 weeks continuously that is followed by a rest period of 7 days for allowing the body to adjust with it. Depending on how your body responds to the treatment, the doctor will recommend further alterations. The standard gap between two doses is recommended to be at least 24 hours. In case you miss a single dose, it is absolutely prohibited to take two Palbociclib capsules at a time. Contact your doctor under such circumstances.

The aromatase inhibitor drugs that are prescribed with this medication are required to be consumed once a day, for a period of 28 days at a stretch. However, Ibrance Palbociclib is also prescribed in combination with Fulvestrant, where the body hasn’t responded properly to previous treatments or for patients who have had hormone therapy. It is given in two injections for the first 3 doses every 2 weeks. As the treatment progresses, the dose is reduced to only one injection a month. 

Precautionary Measures

There are certain precautionary measures that need to be taken before starting this breast cancer medication to avoid high-risk situations afterward. 

• Grapefruit or grapefruit juice must be avoided while you are taking Palbociclib. 

• It is very important to determine whether you are allergic to any of the ingredients in the drug. That is why a series of medical tests is mandatory before starting treatment. For instance, this drug consists of lactose. Hence, it can create problems for lactose intolerant patients. 

• Make sure to tell your doctor the current medicines that you’re using. Otherwise, it can cause an unhealthy reaction in the body and even affect the treatment. 

• Patients with interstitial lung diseases like pneumonitis need to use this medicine with caution because it can cause breathing troubles and make the condition worse. 

• Infertility issues are associated with this medication. It can also harm the unborn fetus. If you have finished therapy, wait for at least 3 months before trying to get pregnant. 

• Avoid coming in contact with people who have infections because Palbace reduces the number of WBC in your body, thus making you prone to catching infections. 

• If you vomit after taking medicine, do not take another one. Wait until the time of your next dose and continue regularly. 

• Prescriptive or non-prescriptive vitamin supplements must also be avoided during this period. 

Palbociclib Side Effects

• Bleeding gums

• Black stools

• Fever and chills

• Urine inflammation 

• Swollen glands

• Ulcers or mouth sores

• Unusual bruising and bleeding 

• Tiredness 

The side effects that need immediate medical attention are:

• If your body has a high temperature (more than 37.5 degree Celsius)

• If you experience serious difficulty in breathing that results in chest pains

Currently, the cost of Palbociclib 125 mg (per cycle) is very high, around 90,000 INR. Due to the high Palbociclib price, it is advised to have medical insurance so that the treatment expenses are covered, and the patient can recover safely. 

FAQ's

What kind of drug is Palbociclib?

Palbociclib specifically is an anti-cancer drug, which blocks proteins named cyclin dependent kinase inhibitors. Blocking cyclin dependent kinase inhibitors may slow down the growth of cancerous cells and delay the progression of cancer.

How long do I have to take Palbociclib?

The treatment duration varies from patient to patient. Your healthcare practitioner will fix the number of cycles you require to receive on behalf of your condition, response to treatment and tolerance to adverse reactions. Your healthcare practitioner may reduce your dose or interrupt your treatment temporarily or permanently in case you have certain adverse reactions.

Does Palbociclib treatment require monitoring of blood counts?

Yes, the blood tests are crucial since this drug may reduce the blood counts. The regular blood tests evaluate the effect of Palbociclib on the cells of blood.

Does Palbociclib affect fertility?

The male fertility might be affected while on Palbociclib treatment. Thus, male patients may consider sperm preservation before starting the Palbociclib therapy.

What if Palbociclib used during pregnancy?

Women must be aware that the Palbociclib may have a hazardous effect on the fetus, and thus use should be avoided during pregnancy.

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Disclaimer: The afore-mentioned article is solely for information purpose. We don’t acclaim the effectiveness of the medication.