Exemestane is a steroidal aromatase inactivator and irreversible drug structurally associated with the natural substrate androstenedione. Healthcare professionals recommend the drug Exemestane to treat breast cancer at different stages. Exemestane works as a false substrate for the aromatase enzyme. It is processed to an intermediate that binds irreversibly to the enzyme's active site, causing its inactivation, also known as "suicide inhibition." Exemestane 25 mg tablet is for oral administration. The active ingredient in the tablet is Exemestane, and the inactive ingredients are mannitol, crospovidone, polysorbate 80, hypromellose, colloidal silicon dioxide, microcrystalline cellulose, sodium starch glycolate, magnesium stearate, simethicone, polyethylene glycol 6000, sucrose, magnesium carbonate, titanium dioxide, methylparaben, and polyvinyl alcohol.
Dosage and Administration
The recommended dosage of Exemestane tablets is one 25 mg tablet once daily after a meal in:
Adjuvant treatment of postmenopausal women with estrogen-receptor-positive early breast cancer who have received 2-3 years of tamoxifen and are switched to Exemestane to complete 5 continuous years of adjuvant hormonal therapy.
The treatment of advanced breast cancer in postmenopausal women whose disease has progressed following tamoxifen therapy.
Concomitant use of potent CYP3A4 inducers decreases Exemestane exposure. For patients receiving Exemestane tablets with a strong CYP 3A4 inducer such as rifampicin or phenytoin, the recommended dose of Exemestane tablet is 50 mg once daily after a meal.
After taking Exemestane, one might experience some common side effects, such as hot flashes, headache, depression, difficulty in breathing, feeling tired, trouble sleeping, feeling anxious, joint pain, increased sweating, and upset stomach. If a patient experiences these symptoms and they get worse, immediately consult the doctor.