Introduction: In the year of 2003, Sofosbuvir was approved for medical use in the United States. This drug is used in the treatment of hepatitis C. It is only prescribed along with some combination of peginterferon-alfa, ribavirin, simeprevir, ledipasvir, daclatasvir, or velpatasvir. Cure rates are 30-97% depending on the type of hepatitis C virus involved.
What is Sofosbuvir?
Sofosbuvir is a nucleotide analog medication. It works by inhibiting the hepatitis C NS5B protein. Sofosbuvir is used for treating adult patients with chronic hepatitis C virus (HCV) infection as a component of a combination antiviral treatment regimen:
genotype 1/4 infection either without cirrhosis or with compensated cirrhosis for use along with ribavirin and pegylated interferon.
genotype 2/3 infection either without cirrhosis or with compensated cirrhosis for use along with ribavirin.
Sofosbuvir is used in treating chronic HCV genotype 2/3 infection in pediatric patients aged three years and older either without cirrhosis or with compensated cirrhosis for use along with ribavirin.
How to Take Sofosbuvir?
The drug sofosbuvir is available in the form of tablets. A sofosbuvir 400 mg tablet administered once daily either with or without food. Administer the tablets of sofosbuvir at around the same time every day. Do not crush, break, or chew the sofosbuvir tablets but you must swallow the tablet as a whole with apt water. Administer another tablet of sofosbuvir in case puking occurs within two hours of taking a tablet but avoid taking an additional sofosbuvir dose in case the puking occurs following two hours of administering the tablet.
Price & Storage: The sofosbuvir 400 mg price in India is quite reasonable at each and every certified (ISO & WHO-GDP) pharmaceutical wholesaler or pharmacy. The price of sofosbuvir usually may vary depending on the non-branded (generic) to branded (innovator) version drugs.
Store the tablets of sofosbuvir at room temperature between 15°C and 25°C. The sofosbuvir tablets must be dispensed in the original container. The sofosbuvir tablets are never used in case the seal over the bottle of sofosbuvir is broken or missing. Keep the tablets of sofosbuvir out of reach from children.
Research: Sofosbuvir together with the NS5A inhibitors (daclatasvir, ledipasvir, velpatasvir), have demonstrated sustained virological RRs (Response Rates) of up to 100% in recipients with HCV. Multiple findings suggest that the efficacy rate is noted between 94% and 97%; comparatively greater than previous treatment options.
Sofosbuvir has also been assessed against certain other existing viruses such as the Zika virus and SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2).
Note: The piece of information provided about "What are the medical uses of Sofosbuvir" in this article is just for informational purposes and is not served as a substitute for medical treatment, consultation, diagnosis, of an experienced/qualified healthcare practitioner.