Retevmo (Selpercatinib) is a cancer medicine that shows its action by inhibiting kinase for use in the treatment of:
locally advanced or metastatic non-small cell lung cancer (NSCLC)
advanced or metastatic medullary thyroid cancer (MTC) with a RET mutation
locally advanced or metastatic solid tumors with a RET gene fusion
Retevmo contains the active substance Selpercatinib, and the medicine can only be used under a valid prescription and treatment should be started and supervised by a doctor experienced in the use of cancer treatments.
Dosage-
Retevmo is available as capsules containing 40 or 80 mg Selpercatinib.
The patient is selected on the basis of the presence of rearranged during transfection gene fusion (NSCLC or thyroid) or specific RET gene mutation (MTC)
The dose of Retevmo is based on body weight, and the recommended RETEVMO dosage based on body weight is:
Less than 50 kg: 120 mg
50 kg or greater: 160 mg
Take Retevmo orally twice a day, approximately every 12 hours, until the disease
progression or there is any unacceptable toxicity.
One may take Retevmo capsules with or without food unless coadministered with a proton pump inhibitorCapsules should not be crushed and chewed; they have to be administered orally as a whole.
If there are at least 6 hours left for the scheduled next dose, then only take the missed dose.
Side Effects
The common Retevmo side-effects are loss of appetite, headache, and dizziness.
Changes in the heart’s electrical activity and prolonged QT interval with increased blood pressure is observed.
Abdominal pain or (sense of discomfort), diarrhea, nausea (feeling sick), vomiting, constipation, dry mouth, rash, fever, tiredness, edema, and bleeding are some of the common but serious adverse drug reactions.
A blood test showing reduced lymphocytes increased alanine aminotransferase (ALT), increased aspartate aminotransferase (AST), decreased sodium, and decreased calcium.
Some of the laboratory tests also show changes in liver enzymes and increased creatinine, which indicates problems associated with the kidneys.