Kineret Overview and Indication:
Kineret (anakinra) is an interleukin-1 receptor antagonist. It is supplied in single-use, prefilled, graduated glass syringes. Each graduated syringe usually contains a 100 mg solution. The kineret injection is dispensed in a one-week (7-day) pack and used for the following uses:
CAPS, which is also known as Cryopyrin-associated periodic syndromes to treat neonatal-onset multisystem inflammatory disease (NOMID).
Deficiency of interleukin-1 receptor antagonist (DIRA).
Rheumatoid arthritis (RA), to scale down the signs and symptoms and resist the progression of structural destruction in adult individuals with moderate to severe RA who have failed single or multiple DMARDs given. DMARDs are other than TNFis.
Apart from the US FDA indications, guidelines favor the use of Kineret 100 mg/0.67mL injection to treat SJIA and Still disease.
This IL-1 pharmaceutical product has also been Emergency Use Authorized for Coronavirus disease 2019 in hospitalized patients with positive viral testing with pneumonia requiring auxiliary low- or high-flow oxygen who are at higher risk of developing serious respiratory failure and have an enhanced plasma suPAR.
Dosing of Kineret:
Kineret 100 mg is given by subcutaneous injection. A new syringe is recommended for every single dose. Any left portion after every dose must be discarded. Despite indication, consider the use of the proposed dose every other day for those who have serious renal insufficiency or end-stage renal disease.
CAPS: The proposed dosage is 1-2 mg/kg daily for NOMID patients. The dose of Kineret may be individually net off to the utmost of 8 mg per kg daily to tackle active inflammation. The doses can be adjusted in 0.5 mg/kg to 1 mg/kg increments. Once-daily dosing is typically recommended, but the dose can be split into twice daily use.
DIRA: The proposed dosage for DIRA patients is 1-2 mg/kg per day. The dose may be individually adjusted to the utmost 8 mg/kg per day to tackle active inflammation. Doses can be adjusted in 0.5 mg/kg to 1 mg/kg increments.
Rheumatoid Arthritis (RA): The proposed dosage for RA patients is 100 mg daily at around the same time each day. Higher doses are not liable for a higher response.
Off-label dosing of this medicinal product to treat Still’s disease and SJIA typically varies on behalf of reference, but guidelines favor a dose of 4 mg per kg per day. However, higher doses may be required.
Availability of Kineret:
Kineret comes as 100 mg/0.67 mL prefilled syringes. Each dispensing pack basically contains either 7 or 28 syringes. Kineret injection cost may depend on certain international factors. In case of unavailability, Kineret (anakinra) injection can be imported only after due processes are performed as specified by the CDSCO, which is an Indian authority specialized in dealing with patient-specific licenses.
CDSCO will verify the prescription and Identity of a patient prior to issuing a specific permit to import life-saving medications. Once the Import permits are received, the crucial task is to work with a global supplier who can help facilitate the import of Kineret.
There is a company named THE INDIAN PHARMA (TIP), which is certified by WHO GDP and is dedicated to importing medications in major cities of India and abroad. Kindly Call/WhatsApp: +91 9310090915 or dial TOLL-FREE: 1800-889-1064 to buy Kineret injection online at the latest price. Contact us immediately to get your hard-to-find medicine.
Reference: