As an antibody-drug conjugate composed of a monoclonal antibody (mAb) targeting CD22, it is a cell surface antigen expressed on the cancerous cells in about all patients with B-cell precursor acute lymphoblastic leukemia (ALL), linked to a cytotoxic agent.
Besponsa (inotuzumab ozogamicin) is prescribed for treating adult patients with relapsed/refractory B-cell precursor Acute Lymphoblastic Leukemia.
Method of administration: Every dose of inotuzumab 1 mg should be administered as an IV infusion over a 1-hour period. The appropriate dose must be determined by a doctor.
How does Besponsa work: Besponsa mainly belongs to a class of drugs named monoclonal antibodies. These specifically help by turning on the patient's immune system in order to kill or destroy the cancerous cells.
The inotuzumab injection comes in order to be given directly into a vein (IV) by a healthcare practitioner.
Possible Side Effects: Possible observed side effects of besponsa 1 mg injection is as follows:
Thrombocytopenia
Neutropenia
Infection
Anemia
Leukopenia
Fatigue
Hemorrhage
Pyrexia
Nausea
Headache
Febrile neutropenia
Transaminases increased
Abdominal pain
Gamma-glutamyltransferase increased
Hyperbilirubinemia
Infusion-related reactions
Impaired fertility
Warnings and Precautions:
Serious changes with liver function as well as blockage of small veins in the liver, which may be responsible for causing liver failure and may be life-threatening.
Increased risk of complications and death in patients who will undergo a stem cell transplant following taking besponsa 1 mg.
Bone marrow suppression (Severe) which may be life-threatening.
While on inotuzumab ozogamicin, you may have some reaction to the medicine, these may include: rash, fever or shaking chills, facial swelling, flushing, feeling dizzy, trouble breathing, headache, chest pain and itching.
What are the Possible Contraindications:
Hypersensitivity to the inotuzumab 1 mg or to any of the excipients.
Patients with prior confirmed severe or ongoing veno-occlusive liver disease/sinusoidal obstruction syndrome (VOD/SOS).
Patients with severe ongoing hepatic disease such as cirrhosis, nodular regenerative hyperplasia, and active hepatitis.
Overdose: In the event of besponsa injection overdose, the infusion must be interrupted, and patients need to be monitored for liver as well as haematological toxicities. Re-initiation of this medication at an appropriate therapeutic dose is considered when all existing toxicities have resolved.
Missed Dose: In an event of besponsa missed dose, talk to your healthcare practitioner.
Storage Tips: Store in a refrigerator (2°C to 8°C). Do not freeze. Should be stored in the original carton in order to protect from light.
Price: If you purchase Indian generic, then inotuzumab price is quite reasonable. Prices of besponsa may vary from branded to non-branded drugs. To get inotuzumab at a best price, choose a pharmaceutical wholesaler company that is WHO-GDP and ISO certified.
FAQ
What is the brand name of Inotuzumab ozogamicin?
Besponsa is the brand name of Inotuzumab ozogamicin.
What kind of medication is Besponsa?
Besponsa basically is an antibody-drug conjugate medication.
How Besponsa should be administered?
Besponsa should be administered by intravenous infusion in a doctor's office or clinic.
Is Besponsa safe during pregnancy?
It is not recommended to take Besponsa by pregnant women and women must also not become pregnant while on this medication.
Is it safe to breastfeed while taking Besponsa?
Women should avoid breastfeeding while taking besponsa, and should wait a couple of months following the last dose in order to start breastfeeding
NOTE: The piece of information mentioned about "All about Besponsa (Inotuzumab Ozogamicin)" in this article is just for the informational purposes and is not served as a substitute for medical treatment, consultation, diagnosis of a qualified healthcare provider.